Researchers Uncover Genetic Insights Into Human Diseases Through ORIP’s National Primate Research Centers

Nonhuman primates (NHPs) offer valuable insights into many diseases that affect human health because they are genetically and physiologically very similar to humans (Figure 1). ORIP’s National Primate Research Centers (NPRC) Consortium maintains NHP colonies for use by the biomedical research community. Dr. Jeffrey Rogers, Core Scientist at the Wisconsin NPRC and Associate Professor at the Baylor College of Medicine (BCM), is leading efforts to identify naturally occurring mutations within NHP colonies across the NPRCs and other primate centers. By identifying naturally occurring mutations and applying machine-learning approaches, researchers can discover and develop animal models more quickly and efficiently than is possible through other methods, such as CRISPR gene editing. This work will help researchers study NHP models for both rare and common chronic diseases, leading to potential new treatments for patients...

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